Playing House

The Dangers of Playing House: Celia’s Subversive Role in As You Like It

Playing a dirty trick on airway smooth muscle: house dust mite does it again.

I ncreased airway smooth muscle (ASM) mass is a hallmark of asthma and is thought to be the main contributor to the increased airway hyperresponsiveness seen in asthmatics [1]. This increase is related to disease severity (reviewed in [2]) and caused by hyperplasia alone or in combination with hypertrophy, depending on the generation of airways [3, 4]. Why and how ASM mass is increased is incom...

Investigating Orosi* in Tabriz Qajar houses (Case studies: Mashrooteh House, Heydarzadeh House, Nikdel House)

Iranian architecture has beautiful embellishments that are made of different materials such as tiles, plaster, pottery, stone and wood. Although due to Iran’s hot and dry climate, wood embellishments are less being used, in some cases they have a special and unique place in Iranian architecture. Orosi windows are one of these embellishments which have a special place in various types of archite...

Investigating Orosi* in Tabriz Qajar houses (Case studies: Mashrooteh House, Heydarzadeh House, Nikdel House)

Iranian architecture has beautiful embellishments that are made of different materials such as tiles, plaster, pottery, stone and wood. Although due to Iran’s hot and dry climate, wood embellishments are less being used, in some cases they have a special and unique place in Iranian architecture. Orosi windows are one of these embellishments which have a special place in various types of archite...

Playing FullBAK

BAK is a pro-apoptotic BCL-2 protein that forms toxic mitochondrial pores in response to cellular stress. A membrane-embedded protein historically refractory to recombinant expression in full-length form, BAK plays it close to the vest. We recently produced monomeric, full-length BAK (FL-BAK) for the first time, 1 providing new opportunities to interrogate its activation mechanism as compared w...